Beginning in the 1890s, the Russian physiologist Ivan Pavlov, originally studying the digestive systems of dogs, noticed that his laboratory dogs had begun salivating at the sound of a technician's footsteps before food was even presented, and he redirected his research to systematically investigate the phenomenon. By repeatedly pairing a neutral stimulus, such as the sound of a metronome or bell, with the presentation of food, Pavlov showed that dogs could learn to salivate in response to the neutral stimulus alone, a learned association he called a conditioned reflex. The work, for which Pavlov received the 1904 Nobel Prize in Physiology or Medicine (awarded for his earlier digestive research rather than conditioning itself), established classical conditioning as a foundational concept in the scientific study of learning and behavior, and shaped the subsequent development of behaviorist psychology.
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Pavlov ran the salivary-conditioning experiments with dogs at the Institute of Experimental Medicine from the 1890s through the early 1900s.
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