Biochemistry studies the chemical processes and substances occurring within living organisms, applying the methods of chemistry to biological questions such as how enzymes catalyse reactions, how cells extract energy from food, and how genetic information is encoded and expressed. It emerged as a distinct discipline from the late nineteenth century onward, as chemists including Emil Fischer began applying structural chemistry to sugars, proteins and other molecules of biological origin, work that itself extended the molecular stereochemistry Louis Pasteur had opened in 1848, and matured through the twentieth century with the discovery of metabolic pathways such as Hans Krebs's citric acid cycle. This atlas records its first dedicated foothold here in Fischer's lock and key model of enzyme specificity and Krebs's citric acid cycle, both wired to biology and chemistry as the discipline's parent fields.
Facts
Central QuestionBy what molecular mechanisms is genetic information transferred and gene expression regulated, a question sharpened by the discovery of RNA interference as a silencing pathway? 1 ScopeBiochemistry studies the chemical processes within and relating to living organisms, organized around three core areas: structural biology, enzymology and metabolism. 1 SignificanceThe word biochemistry is often credited to Carl Neuberg in 1903, though the discipline's founding figures worked earlier. Emil Fischer's studies of proteins and sugars, Friedrich Wohler's synthesis of an organic compound from inorganic starting materials, and Eduard Buchner's demonstration that fermentation could proceed outside a living cell together established that the chemistry of life follows the same laws as chemistry anywhere else. 1 Disputed
Founded YearThe German term Biochemie was already in use by 1877 through Felix Hoppe-Seyler, but biochemistry as a named, independent discipline is more often dated to Carl Neuberg's 1903 coinage of the modern term and the early 20th century institutional consolidation that followed, including the founding of the Biochemical Society in London in 1911. Biochemistry
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Connections
Associated With
Source Biochemical Society, About Us
Founded By
Source Wikipedia: Biochemistry
Has Scientist
Source Dorothy Hodgkin (Wikipedia)
Source Eduard Buchner (Wikipedia)
Source Frederick Sanger (Wikipedia)
Source Kamala Sohonie (Wikipedia)
Source Kary Mullis (Wikipedia)
Has Theory
Source Alkoholische Garung ohne HefezellenEduard Buchner
Source Structure of Rhombohedral 2 Zinc Insulin CrystalsM. J. Adams, T. L. Blundell, E. J. Dodson, G. G. Dodson, M. Vijayan, E. N. Baker, M. M. Harding, Dorothy C. Hodgkin, B. Rimmer and S. Sheat
Source The Disulphide Bonds of InsulinA. P. Ryle, Frederick Sanger, L. F. Smith and Ruth Kitai
Studies
Source Adenosine Triphosphate (Wikipedia)
Source Enzyme (Wikipedia)
Source Metabolism (Wikipedia)
Source Polymerase Chain Reaction (Wikipedia)
Source Protein Structure (Wikipedia)
Uses
Source Gas Chromatography (Britannica)
NMR spectroscopy is a principal technique for determining protein and nucleic-acid structure in solution.
Source Nuclear Magnetic Resonance Spectroscopy (Wikipedia)
Source Polymerase Chain Reaction (Wikipedia)
The ultracentrifuge spins samples at very high speed to separate macromolecules and organelles by sedimentation, developed by Theodor Svedberg in 1926 for biochemistry.
Sources
1. Wikipedia: Biochemistry
Wikipedialead
Biochemistry, or biological chemistry (distinct from chemical biology), is the study of chemical processes within and relating to living organisms.
- Founded By: Emil Fischer
View the Source 2. Emil Fischer (Britannica)
Gas Chromatography (Britannica)
Nuclear Magnetic Resonance Spectroscopy (Wikipedia)
Polymerase Chain Reaction (Wikipedia)
Wikipedia- Uses: Thermal Cycler
- Studies: Polymerase Chain Reaction
View the Source Kary Mullis (Wikipedia)
Biochemical Society, About Us
Kamala Sohonie (Wikipedia)
WikipediaHas Scientist: Kamala Sohonie, IntroductionQuote, Has Scientist: Kamala Sohonie, Introduction
Kamala Sohonie (18 June 1911-28 June 1998) was an Indian biochemist who in 1939 became the first Indian woman to receive a PhD in a scientific discipline.
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