Disciplines
Biochemistry
Also Known As Biological Chemistry
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Biochemistry studies the chemical processes and substances occurring within living organisms, applying the methods of chemistry to biological questions such as how enzymes catalyse reactions, how cells extract energy from food, and how genetic information is encoded and expressed. It emerged as a distinct discipline from the late nineteenth century onward, as chemists including Emil Fischer began applying structural chemistry to sugars, proteins and other molecules of biological origin, work that itself extended the molecular stereochemistry Louis Pasteur had opened in 1848, and matured through the twentieth century with the discovery of metabolic pathways such as Hans Krebs's citric acid cycle. This atlas records its first dedicated foothold here in Fischer's lock and key model of enzyme specificity and Krebs's citric acid cycle, both wired to biology and chemistry as the discipline's parent fields.
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Central QuestionSourced to the subject's own accountBy what molecular mechanisms is genetic information transferred and gene expression regulated, a question sharpened by the discovery of RNA interference as a silencing pathway? 1 ScopeSourced to the subject's own accountBiochemistry studies the chemical processes within and relating to living organisms, organized around three core areas: structural biology, enzymology and metabolism. 1 SignificanceSourced to the subject's own accountThe word biochemistry is often credited to Carl Neuberg in 1903, though the discipline's founding figures worked earlier. Emil Fischer's studies of proteins and sugars, Friedrich Wohler's synthesis of an organic compound from inorganic starting materials, and Eduard Buchner's demonstration that fermentation could proceed outside a living cell together established that the chemistry of life follows the same laws as chemistry anywhere else. 1 Disputed
Founded YearThe German term Biochemie was already in use by 1877 through Felix Hoppe-Seyler, but biochemistry as a named, independent discipline is more often dated to Carl Neuberg's 1903 coinage of the modern term and the early 20th century institutional consolidation that followed, including the founding of the Biochemical Society in London in 1911. Cross-Tradition Connections
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NMR spectroscopy is a principal technique for determining protein and nucleic-acid structure in solution.
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